Cooling baths are a fundamental part of laboratory equipment, used for cooling and maintaining low temperatures during chemical reactions. Low-temperature reactions can be important for many reasons, such as reducing unwanted side reactions, slowing down reactions that are too fast, and enabling reactions that require low temperatures to proceed. In this blog post, we’ll explore some of the different cooling baths used in chemistry for low-temperature reactions. The ice bath is one of the most common and straightforward cooling baths. It involves filling a container with ice and water, then immersing the reaction vessel into it. Ice baths can maintain temperatures between 0-5 °C, making them useful for reactions that require temperatures below room temperature but not as low as other cooling baths. If sodium chloride is added to the ice bath then temperatures down to -20 °C can be achieved. Dry ice is solid carbon dioxide, which can be used as a cooling agent due to its low temperature. A dry ice bath involves placing dry ice in a container and adding a solvent such as ethanol, acetone, or methanol. The solvent evaporates quickly and cools down the reaction vessel. The most common cooling bath containing dry ice, is a dry ice/acetone bath which is at -78 °C. A variety of solvents can be used with dry ice to give cooling baths of various temperatures. Radleys Cool-It bowls, the Cooled Carousel 6 Reaction Station and the Cooled Carousel 12 Reaction Station can be used down to -85 °C. Some examples of cooling bath mixtures can be found below. Cooling Agent Organic Solvent T (°C) Dry Ice Benzyl alcohol -15 Dry Ice 1,3-Dichlorobenzene -25 Dry Ice o-Xylene -29 Dry Ice 3-Heptanone -38 Dry Ice Acetonitrile -42 Dry Ice Pyridine -42 Dry Ice Cyclohexanone -46 Dry Ice n-Octane -56 Dry Ice Diisopropyl ether -60 Dry Ice Chloroform -61 Dry Ice Ethanol -72 Dry Ice Isopropyl alcohol -77 Dry Ice Acetone -78 Dry Ice Propylamine -83 If very low temperatures are required then cooling baths with liquid nitrogen can be used. A bath of pure liquid nitrogen would be at -196 °C; however this would evaporate very quickly. Liquid nitrogen can be used in conjunction with a variety of solvents to achieve a range of cooling bath temperatures.In conclusion, cooling baths are essential tools for low-temperature reactions in chemistry. The type of cooling bath used depends on the required temperature range and the specific needs of the reaction. By selecting the appropriate cooling bath, chemists can carry out reactions more efficiently and with greater control. You might also be interested in Webinar: Reactions at low temperatures – theory, tools and tips for better efficiencyIn this webinar we will explore the theory of low temperature reactions (thermodynamics vs kinetics), the types of reactions that require cold temperatures and the challenges that chemists face when attempting to maintain low temperatures during reactions. Agenda & registration Videos Downloadable resources Case studies Carousel 6 Plus and Cooled Reaction Stations Brochure Find Out More Carousel 12 Plus and Cooled Reaction Stations Brochure Find Out More Carousel and Cooled Carousel 6 Plus System Guide Find Out More Evaluation of Cooled Carousel 12 Reaction Station document Find Out More Evaluation of Cooled Carousel 6 Reaction Station document Find Out More Cooled Carousel 6 Plus Instructions Find Out More Cooled Carousel 12 Plus Instructions Find Out More Case studies Achieving the most efficient and convenient experiments Find Out More Carousel 12 and 6 improve productivity Find Out More Tornado, Storm and Carousel 6 Plus work in harmony to help achieve results in China Find Out More Explore the range Cooled Carousel 6 Plus Reaction Station Find Out More Cooled Carousel 12 Plus Reaction Station Find Out More Parallel Reaction Stations Find Out More