Streamlining Chemical Synthesis DoE for Successful Process Development

When trying to develop synthetic routes that are safe, cost-effective, reproducible and efficient, Process Development chemists often use a Design of Experiments approach. DoE identifies the critical factors required to achieve optimal reaction conditions through a multivariate approach.

Process development chemistry can also be impacted by the experimental set up. Traditional systems use a round bottom flask with heating-only equipment but they suffer from poor temperature control, which can often lead to inaccurate results and can affect scale-up cost and timeline.

This paper follows the Process R&D group at Purolite aiming to improve the speed and quality of their process development using parallel synthesis and an alternative synthetic chemistry set up.

---

Read the full White Paper to find how Purolite improved their Process R&D and significantly reduced the translation time from small-scale to large- and manufacturing-scale reactions.

Download the White Paper