White Paper - Crystallisation in pharmaceutical processes

Introduction & Synopsis

Do you want to expand your crystallisation knowledge?

If you are a crystallisation chemist or would just like to know more about this topic then read our latest White Paper – Crystallisation in pharmaceutical processes.

The paper covers crystallisation methods, purification, polymorphism, and more.

Abstract

The different aspects of crystallisation development have been described in detail in the literature and this paper aims to provide an overview of the crystallisation process.

The background to crystallisation processes is described, as well as the four main types of crystallisations: cooling, anti-solvent, reactive and pH controlled. Examples of each crystallisation type are given including developments and applications.

Find out more about crystallisation in pharmaceutical process.

Download the White Paper

Crystallisation allows the reaction, work-up, and purification to be performed in the same vessel, so we are always delighted to develop a method that is robust at scale. High purity material is obtained, allowing for costly and impractical (at scale) chromatography to be removed from the process.Dr Paul Shaw, Senior Chemist, Charnwood Molecular

Webinar: Why Crystallise?

Introduction to techniques and tips on equipment setup

In this webinar we discuss the benefits of crystallisation as a tool for product isolation, versus other common techniques.

We look at the methods of performing crystallisations used by chemists, with examples, including cooling, anti-solvent, pH adjustment and reactive crystallisations. There will be discussion of the Meta Stable Zone (MSZ) and use of phase diagrams.

Finally, we discuss what equipment is most effective for performing crystallisations along with some tips to improve your crystallisation processes.

Watch webinar on demand