Usona chooses Reactor-Ready for Controlled Crystal Engineering Process for Large-Scale Synthesis of Psilocybin Polymorphs. Contacts: Robert Kargbo Ph.D, CMC Project Manager Organisation: Usona Institute, Madison, WI Country: USA Product: Reactor-Ready Lab Reactor Case Study No: CS1036 SituationNew research by Usona Institute aimed to identify the most favourable environments to achieve consistency and reproducibility of pharmaceutical psilocybin produced at large scale. The ability of a unique crystalline arrangement to solidify in more than one form, called polymorphs, could be optimised using precise combinations of engineering controls including temperature, cooling rate, saturation, stirring speed, and drying mode. Outcomes Usona chemists designed a thermodynamically controlled crystal engineering process using measurement of the metastable zone width (MSZW) and nucleation induction to produce a unique crystalized form of psilocybin with stronger interactions, controlled particle size distribution (PSD), and improved impurity profile. A high-resolution inline microscopy viewer allowed for real-time monitoring of the crystallization process and measurement of particle size distribution. ResultsRadleys supplied the Reactor-Ready system to Usona Institute which they chose to use in this study: “The Reactor-Ready Lab Reactor has flexible framework, which made it convenient for the chemistry performed. The loading and unloading features allowed safe and secured manipulations.” Robert Kargbo, CMC Project Manager at Usona Institute The Reactor-Ready Lab Reactor has flexible framework, which made it convenient for the chemistry performed. The loading and unloading features allowed safe and secured manipulations. Robert Kargbo Ph.D, CMC Project Manager at Usona Institute Provided as open accessAppreciating that these structures have been explored and synthesized for decades, the study published in ACS Omega is supported through Usona as an open access paper. To learn more about Usona, visit www.usonainstitute.org Explore the range Reactor-Ready Lab Reactor Find Out More Reactor-Ready Duo Lab Reactor Find Out More Reactor-Ready Reaction Vessels & Accessories Find Out More