Usona chooses Reactor-Ready for Controlled Crystal Engineering Process

New research by Usona Institute aimed to identify the most favourable environments to achieve consistency and reproducibility of pharmaceutical psilocybin produced at large scale.

The ability of a unique crystalline arrangement to solidify in more than one form, called polymorphs, could be optimised using precise combinations of engineering controls including temperature, cooling rate, saturation, stirring speed, and drying mode.

1. Usona chemists designed a thermodynamically controlled crystal engineering process using measurement of the metastable zone width (MSZW) and nucleation induction to produce a unique crystalized form of psilocybin with stronger interactions, controlled particle size distribution (PSD), and improved impurity profile.
2. A high-resolution inline microscopy viewer allowed for real-time monitoring of the crystallization process and measurement of particle size distribution.

Radleys supplied the Reactor-Ready system to Usona Institute which they chose to use in this study:

“The Reactor-Ready Lab Reactor has flexible framework, which made it convenient for the chemistry performed. The loading and unloading features allowed safe and secured manipulations.” Robert Kargbo, CMC Project Manager at Usona Institute