Usona chooses Reactor-Ready for Controlled Crystal Engineering Process for Large-Scale Synthesis of Psilocybin Polymorphs.

Reactor in use at Usona

Contacts: Robert Kargbo Ph.D, CMC Project Manager

Organisation: Usona Institute, Madison, WI

Country: USA

Product: Reactor-Ready Lab Reactor

Case Study No: CS1036

Situation

New research by Usona Institute aimed to identify the most favourable environments to achieve consistency and reproducibility of pharmaceutical psilocybin produced at large scale.

The ability of a unique crystalline arrangement to solidify in more than one form, called polymorphs, could be optimised using precise combinations of engineering controls including temperature, cooling rate, saturation, stirring speed, and drying mode.

Outcomes

  1. Usona chemists designed a thermodynamically controlled crystal engineering process using measurement of the metastable zone width (MSZW) and nucleation induction to produce a unique crystalized form of psilocybin with stronger interactions, controlled particle size distribution (PSD), and improved impurity profile.
  2. A high-resolution inline microscopy viewer allowed for real-time monitoring of the crystallization process and measurement of particle size distribution.

Results

Radleys supplied the Reactor-Ready system to Usona Institute which they chose to use in this study:

“The Reactor-Ready Lab Reactor has flexible framework, which made it convenient for the chemistry performed. The loading and unloading features allowed safe and secured manipulations.” Robert Kargbo, CMC Project Manager at Usona Institute

The Reactor-Ready Lab Reactor has flexible framework, which made it convenient for the chemistry performed. The loading and unloading features allowed safe and secured manipulations. Robert Kargbo Ph.D, CMC Project Manager at Usona Institute
Usona Institute

Provided as open access

Appreciating that these structures have been explored and synthesized for decades, the study published in ACS Omega is supported through Usona as an open access paper.

To learn more about Usona, visit www.usonainstitute.org