Sai Life Sciences is a leading Contract Research Development and Manufacturing Organisation (CRDMO), who specialise in providing innovative and cost-effective solutions for the discovery, development, and manufacture of pharmaceuticals.

Their UK site faced the challenge of optimising distillation processes and concentrating column fractions efficiently in their pharmaceutical intermediate manufacture. Seeking solutions to enhance productivity and safety, they turned to Heidolph’s Hei-VAP Industrial rotary evaporator, supplied by Radleys.

Challenge

Sai Life Sciences required a large-scale rotary evaporator to support distillation processes and the concentration of column fractions in its scale-up facilities.

These workflows can involve significant solvent volumes and require equipment that supports efficient processing, safe handling and reliable day-to-day operation. The team needed a robust solution that could be used confidently by chemists working with pharmaceutical intermediates at larger operating volumes.

Solution

Implementing the Hei-VAP Industrial rotary evaporator supplied by Radleys provided Sai Life Sciences with a reliable large-scale evaporation solution for its scale-up facilities.

The system offered the capacity and control required for distillation and concentration workflows, supporting faster processing of materials. The vapour temperature sensor is used to monitor solvent boiling behaviour, supporting process control and understanding.

Heidolph Hei-VAP Industrial Rotary Evaporator

Benefits

Time Savings: The Hei-VAP Industrial supported distillation and concentration workflows, helping Sai Life Sciences process materials effectively within its manufacturing operations.

Enhanced Safety: Safety features such as PMMA safety panels provided peace of mind to operators, helping to support a safer working environment.

Improved Efficiency: The ability to concentrate column fractions productively simplified complex processes, enabling Sai Life Sciences to work effectively with pharmaceutical intermediates at scale.

Safe Flask Handling: The Easy Lock flask attachment supported safe flask exchanges and provided peace of mind during operations involving high fill volumes.

Customer Support: The after-sales service from Radleys and Heidolph provided technical support and equipment troubleshooting advice, helping to keep the equipment operating at its best.

Process Details

Sai Life Sciences primarily uses the Hei-VAP Industrial for distillations and concentrating column fractions in its pharmaceutical intermediates manufacturing. Operating volumes typically range from one to 20 litres, with a focus on organic chemistry and early-phase intermediates.

Conclusion

The implementation of the Hei-VAP Industrial rotary evaporator has supported Sai Life Sciences’ pharmaceutical intermediates manufacturing processes, helping the team carry out distillation and concentration workflows efficiently and safely at scale.

Through its partnership with Heidolph and Radleys, Sai Life Sciences continues to advance pharmaceutical manufacturing capabilities and deliver high-quality solutions to clients worldwide.